Select Publications

Hughey, C. C., & Crawford, P. A. (2019). Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword. Cell Metabolism, 29(6), 1236-1238. PMID: 31167118 doi: 10.1016/j.cmet.2019.05.013

Hughey, C. C., James, F. D., Wang, Z., Goelzer, M., & Wasserman, D. H. (2019). Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation. Molecular metabolism. PMID: 30850319 doi: 10.1016/j.molmet.2019.02.006

Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H., & Sakamoto, K. (2018). Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. Nature medicine, 24(9), 1395-1406. PMID: 30150719 doi: 10.1038/s41591-018-0159-7

Hughey, C. C., Trefts, E., Bracy, D. P., James, F. D., Donahue, E. P., & Wasserman, D. H. (2018). Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. The Journal of biological chemistry, 293(30), 11944-11954. PMID: 29891549 doi: 10.1074/jbc.RA118.002568

Hughey, C. C., James, F. D., Bracy, D. P., Donahue, E. P., Young, J. D., Viollet, B., Foretz, M., & Wasserman, D. H. (2017). Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice. The Journal of biological chemistry, 292(49), 20125-20140. PMID: 29038293 doi: 10.1074/jbc.M117.811547

Hasenour, C. M., Ridley, D. E., James, F. D., Hughey, C. C., Donahue, E. P., Viollet, B., Foretz, M., Young, J. D., & Wasserman, D. H. (2017). Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation. PloS one, 12(1), e0170382. PMID: 28107516 doi: 10.1371/journal.pone.0170382

Hasenour, C. M., Wall, M. L., Ridley, D. E., Hughey, C. C., James, F. D., Wasserman, D. H., & Young, J. D. (2015). Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo. American journal of physiology. Endocrinology and metabolism, 309(2), E191-203. PMID: 25991647 doi: 10.1152/ajpendo.00003.2015

Hughey, C. C., Wasserman, D. H., Lee-Young, R. S., & Lantier, L. (2014). Approach to assessing determinants of glucose homeostasis in the conscious mouse. Mammalian genome : official journal of the International Mammalian Genome Society, 25(9-10), 522-38. PMID: 25074441 doi: 10.1007/s00335-014-9533-z